Meta-analysis of the Effects of Intermittent Hypoxia on Learning and Memory in Mammals
Objective Existing studies have shown that hypoxia affects mammalian brain function.In this paper,Morris water maze experiment was employed to analyze the effects of intermittent hypoxia on learning and memory ability of lactation.Method The retrieval time was limited to February 25,2023 through the databases of CNKI,VIP database,WANFANG data,Web of Science,PubMed and Elsevier.RevMan 5.3 software was used for statistical analysis of the extracted data,Then sensitivity analysis was used to evaluate the quality of the included studies.Result A total of 24 articles and 263 subjects were included in this study.In the Morris Water Maze experiments,the escape latency of rats/mice was increased after treated with intermittent hypoxia for two weeks compared with the control group[SMD=4.17,95%CI(3.46,4.89),P<0.01].The time of rats/mice crossing the target quadrant was decreased[SMD=-3.07,95%CI(-3.56,-2.58),P<0.01].After treatment with intermittent hypoxia for four weeks,the escape latency increased[SMD=8.03,95%CI(6.21,10.40),P<0.01];The time across the target quadrant shortened[SMD=-6.79,95%CI(-8.60,-4.99),P<0.01].Conclusion Treated with intermittent hypoxia,the escape latency of rats/mice in the water maze rises,and the time of cross the target quadrant is shortened,indicating the learning and memory ability of mice/rats is impaired.
intermittent hypoxiaMeta-analysisMorris water maze
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