摘要
精神障碍指由于大脑机能紊乱,导致患者精神活动(情感、认知、意志等)产生障碍.内隐的精神障碍常伴随外显的行为异常.构建精神障碍模式动物对探究精神障碍的发病机制至关重要,而用动物行为学的实验方法测量精神障碍模式动物的行为表型,对评价精神障碍相关研究的有效性具有重要意义.因此,本文基于精神障碍模式鼠的相关研究,总结常见精神障碍(抑郁障碍、焦虑障碍、双相情感障碍、孤独症谱系障碍、注意缺陷多动障碍、创伤后应激障碍、强迫症)的行为学测验原理与方法,以期对精神病学的基础研究提供参考.
Abstract
Mental disorders refer to the disorders in the mental activity(affection,cognition,and volition,etc)of patients,which are caused by the brain dysfunction.Implicit mental disorders are usually accompanied by explicit abnormal behaviors.Building mental disorder-like animals is vital for exploring the pathogenesis of mental disorders,and is meaningful for evaluating the validity of the researches on mental disorders.Therefore,based on previous studies about mental disorder-like rodents,we summarized the principles and method for behavioral tests of some mental disorders(depression,anxiety,bipolar disorder,autism spectrum disorder,attention deficit hyperactivity disorder,post-traumatic stress disorder,obsessive-compulsive disorder),expecting to provide a reference for the fundamental researches of psychiatry.
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维普
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