Objective Aluminum ash residue extract(AAE)and constructed a rat lung inhalation model to test the effects of AAE on the lungs.Method The physiological and biochemical characteristics of the lungs,as well as the degree of inflammation in the lungs,were examined for different doses and dyeing times of AAE.Result The experimental result showed that nebulized inhalation of AAE could lead to lung injury in rats within a short period of time,even at low doses,and the degree of injury was significantly positively correlated with the inhalation dose and time.The experimental result further indicated that the lung injury caused by the inhalation of AAE was mainly due to the activation of lung neutrophils by AAE,which promoted the release of more pro-inflammatory factors TNF-α,IL-6,IL-1β,and inflammatory mediators MPO and MDA.Conclusion The result of this study reveal the possibility and potential mechanism of industrial solid waste aluminum ash to respiratory tract injury,and provide a reference for promoting the standardized treatment of industrial waste in aluminum manufacturing enterprises.
关键词
铝灰渣提取物/呼吸系统毒性/大鼠模型
Key words
aluminum ash extract/respiratory system toxicity/rat model
维普
万方数据