Recurrent aphthous ulcer is the most common oral mucosal disease.Because of its unknown etiology,the treatment is mainly to relieve pain,reduce the number of recurrences,and prolong the interval period.The establishment of a good animal model is essential to study the etiology and treatment of recurrent aphthous ulcers.At present,the method for the establishment of recurrent aphthous ulcers include mechanicalmethod,This article reviews several common methods for establishing models and evaluating the results of recurrent aphthous ulcers,and compares the advantages and disadvantages of the models.The aim is to provide a basis for researchers to select models for studying the pathogenesis and drug treatment of recurrent aphthous ulcers.
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