摘要
目的:探讨经阴道子宫动脉下行支结扎作为Ⅱ型、Ⅲ型以及包块型的剖宫产瘢痕部位妊娠(CSP)预处理方式的可行性.方法:回顾性分析2021 年1 月至2022 年12 月湖北省妇幼保健院诊治的39 例Ⅱ型、Ⅲ型及包块型CSP的患者作为观察对象,根据预处理方式不同分为两组,其中以经阴道子宫动脉下行支结扎作为预处理的患者为结扎组(n =20),以子宫动脉栓塞作为预处理的患者为栓塞组(n =19),两组患者在预处理后均行腹腔镜妊娠组织清除+子宫瘢痕切除术.分析并比较两组患者的一般资料、术中、术后及随访临床资料情况.结果:结扎组与栓塞组比较,年龄、停经时间、妊娠次数、CSP类型、瘢痕妊娠部位子宫肌层厚度、孕囊大小、术前抗米勒管激素(AMH)、瘢痕处血流阻力指数(RI)、术前白细胞计数、术前C-反应蛋白(CRP)及血红蛋白(Hb)、术后CRP、术后白细胞计数、术后Hb、人绒毛膜促性腺激素(hCG)下降比、自主通气时间、术后1 月AMH和子宫内膜厚度、术后hCG恢复正常时间,差异均无统计学意义(P>0.05).结扎组的术中出血量多于栓塞组,住院时间和住院费用少于栓塞组,差异有统计学意义(P<0.05).术后并发症(腹痛、月经量变化情况、宫腔粘连、卵巢功能受损)结扎组(0)少于栓塞组(21.05%),差异有统计学意义(P<0.05).结论:相比于子宫动脉栓塞作为Ⅱ型、Ⅲ型以及包块型CSP预处理方式,经阴道子宫动脉下行支结扎具有安全有效、操作便捷、费用低,术后并发症少,可以作为急诊及非紧急情况下Ⅱ型、Ⅲ型及包块型CSP的预处理方式.
Abstract
Objective:To assess the feasibility of transvaginal ligation of inferior uterine artery branches as a preoperative intervention for Type Ⅱ,Type Ⅲ,and mass cesarean scar pregnancy(CSP)at the cesarean scar site.Methods:A retrospective analysis was conducted on 39 patients with Type Ⅱ,Type Ⅲ,and mass CSP treated at the Maternal and Child Health Hospital of Hubei Provincial from January 2021 to December 2022.Patients were categorized into two groups based on different pretreatment,the ligature group(n =20)underwent transvaginal uterine artery branch ligation,while the embolization group(n =19)underwent uterine artery embolization,both groups underwent laparoscopic pregnancy tissue removal and cesarean scar excision post-pretreatment.General data,intraoperative and postoperative clinical parameters,as well as follow-up data,were analyzed and compared between the two groups.Results:Compared with the embolization group,age,menopause time,number of preg-nancies,CSP type,myometrium thickness at the site of scar pregnancy,gestational sac size,preoperative anti-Mil-lerian hormone(AMH),blood flow resistance index(RI)at the scar site,preoperative white blood cell count,preop-erative C-reactive protein(CRP)and hemoglobin(Hb),postoperative CRP,preoperative white blood cell count,postoperative Hb,human chorionic gonadotropin(hCG)decreased ratio,spontaneous ventilation time,AMH and endometrial thickness at 1 month after surgery,there was no significant difference in the time of hCG return to normal after surgery(P>0.05).The intraoperative blood loss in the ligation group was higher than that in the em-bolization group,and the length of hospital stay and hospitalization cost were lower than those in the embolization group,and the difference was statistically significant(P<0.05).The postoperative complications(abdominal pain,changes in menstrual flow,intrauterine adhesions,and impaired ovarian function)were less in the ligation group(0)than in the embolization group(21.05%),and the difference was statistically significant(P<0.05).Conclu-sions:Transvaginal uterine artery branch ligation for Type Ⅱ,Type Ⅲ,and mass CSP pretreatment,in compari-son to uterine artery embolization,demonstrates safety,effectiveness,ease of operation,cost-effectiveness,and reduced postoperative complications.This approach proves to be a viable option for both emergency and non-e-mergency cases of Type Ⅱ,Type Ⅲ,and mass CSP.
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