目的:荟萃分析眼动脉多普勒超声各项指标与子痫前期(PE)严重程度之间的关系。方法:在 PubMed、Web of Science、Embase 和 the Cochrane Library 中系统检索 1995年1月至2023年3月期间相关的文献。纳入PE、重度子痫前期(sPE)患者和健康孕妇眼动脉多普勒超声指标，包括收缩期峰值速度(PSV)、舒张末期速度(EDV)、阻力指数(RI)、搏动指数(PI)、第二个峰值流速与初始峰值流速的比值(PR)进行研究。采用随机效应模型作为汇总分析方法，用I2值评估异质性。采用具有95％CI的标准化均数差(SMD)来评估眼动脉多普勒超声指标与PE患者严重程度的关系。结果:最终纳入8篇文献进行荟萃分析。与PE患者相比，sPE患者的PI值降低(SMD-0。56，95％CI-0。92～-0。20，P=0。000)，EDV 值升高(SMD 0。47，95％CI 0。12～0。83，P=0。028)和 PR 值升高(SMD 0。96，95％CI 0。13～1。78，P=0。023)。但PE和sPE患者之间PSV值和RI值的差异无统计学意义(P=0。361，P=0。626)。结论:眼动脉多普勒超声指标(PI、EDV和PR)可能有助于识别PE发展(特别是鉴别sPE)，进而帮助临床医生尽早采取必要的预防措施。
The Association between Ophthalmic Artery Doppler Variables and the Severi-ty of Pre-eclampsia:a Meta-analysis
Objective:To investigate the association between the Doppler variables of the ophthalmic artery with the severity of preeclampsia(PE).Methods:Systematic literature was searched between January 1995 and March 2023 in PubMed,Web of Science,Embase,and the Cochrane Library.Studies comparing ophthalmic artery Doppler variables,including peak systolic velocity(PSV),end-diastolic velocity(EDV),resistive index(Rl),pulsa-tility index(PI),and peak ratio(PR,the ratio of the flow velocity of the second peak to that of the initial peak)in patients with PE,severe preeclampsia(sPE),and healthy pregnant women were included.The random-effects model was adopted as the method of pooled analysis,and the I2value was used to assess heterogeneity.The pooled standardized mean difference(SMD)with 95％confidence interval(CI)was used to estimate the associa-tion between ophthalmic artery Doppler variables and PE patient's characteristics.Results:Eight retrospective studies were eventually included in this Meta-analysis.Our pooled results suggested that compared with PE ca-ses,sPE patients had lower PI levels(SMD-0.56,95％CI-0.92～-0.20,P=0.000),higher EDV levels(SMD 0.47,95％CI 0.12～0.83,P=0.028)and higher PR levels(SMD0.96,95％CI 0.13～1.78,P=0.023).Howev-er,there was no significant difference between PE and sPE patients about the PSV and RI(P=0.361,P=0.626).Conclusions:This review demonstrates that ophthalmic artery Doppler variables(PI,EDV and PR)could be useful for predicting PE and PE development(especially in identifying sPE),which in turn may help the practitioner in the management of these complicated cases and in taking early necessary precautions.
万方数据
维普
