外用红色诺卡氏菌细胞壁骨架治疗子宫颈锥切术后高危型HPV持续感染的临床疗效分析
Clinical Efficacy Analysis of Red Nocardia Rubra Cell Wall Skeleton in the Treatment of Persistent High-Risk HPV Infection after Cervical Conization
朱瑞森 1赵淑萍 1汤云 1郑德璇 1邹存华1
作者信息
- 1. 青岛大学附属青岛妇女儿童医院妇科中心,山东 青岛 266000
- 折叠
摘要
目的:探讨外用红色诺卡氏菌细胞壁骨架(Nr-CWS)治疗子宫颈锥切术后高危型人乳头瘤病毒(HR-HPV)持续感染的临床疗效.方法:选择2019 年1 月至2021 年1 月因HR-HPV感染引起子宫颈高级别上皮内病变(HSIL),于青岛大学附属青岛妇女儿童医院行子宫颈冷刀锥切术,术后6个月复查HR-HPV持续感染的69 例患者为研究对象,并随机分为治疗组(Nr-CWS治疗 1 个疗程,36 例)和对照组(仅观察,33 例).统计患者治疗有效率、阴道微生态变化及副反应发生的情况.结果:①69 例患者中,治疗组治疗有效率(80.56%)明显高于对照组(39.39%),差异有统计学意义(P<0.05).②治疗组乳杆菌患者的比率较对照组增加明显(77.78%vs.45.45%,P<0.05);治疗组pH值≥4.6、白细胞酯酶(LE)阳性患者的比率较对照组及治疗前均有明显降低,差异有统计学意义(P<0.05).③治疗组 36 例患者中发热 5 例,下腹坠胀感 5 例,腹泻 1 例,皮疹 1 例.结论:Nr-CWS治疗子宫颈锥切术后持续HR-HPV感染疗效较好,阴道微生态环境指标(乳杆菌、LE、pH值≥4.6)改善明显,且无严重副反应发生,但仍需从卫生经济学角度出发,根据患者情况综合考虑.
Abstract
Objective:To investigate the clinical efficacy of external application of red nocardia rubra cell wall skeleton(Nr-CWS)in the treatment of persistent infection of high-risk human papilloma virus(HR-HPV)after cervi-cal conization.Methods:The patients with high-grade cervical intraepithelial lesion(HSIL)caused by HR-HPV in-fection who underwent cervical cold knife conization at the Qingdao Women's and Children's Hospital Affiliated to Qingdao University between January 2019 and January 2021 were selected.69 patients with persistent HR-HPV infection were randomly divided into treatment group(n =36)and control group(n =33).The effective rate of treatment,the change of vaginal microecology and the occurrence of adverse reactions were analyzed.Results:①Among the 69 patients,the effective rate of treatment in the treatment group(80.56%)was significantly higher than that in the control group(39.39%)(P<0.05).②The rate of Lactobacillus in the treatment group was signif-icantly higher than that in the control group(77.78%vs.45.45%,P<0.05).The percentage of patients with pH≥4.6 and positive leukocyte esterase(LE)in the treatment group was significantly lower than that in the con-trol group and before treatment(P<0.05).③In the treatment group,there were 5 cases of fever,5 cases of ab-dominal heaving,1 case of diarrhea and 1 case of skin rash.Conclusions:Nr-CWS has a better therapeutic effect on persistent HR-HPV infection after cervical conization,significant improvement in vaginal microenviron-ment indicators(lactobacillus,LE,pH≥4.6),and no serious adverse reactions.However,it still needs to be con-sidered comprehensively from the perspective of health economics and based on the patient's basic situation.
关键词
子宫颈高级别上皮内病变/锥切术后/高危型HPV持续感染/红色诺卡氏菌细胞壁骨架Key words
High-grade cervical intraepithelial lesion/After cervical conization/Persistent infection of HR-HPV/Red nocardia rubra cell wall skeleton引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据