Correlation between Fasting Plasma Glucose in Early Pregnancy and Gesta-tional Diabetes Mellitus
Objective:To investigate the relationship between fasting plasma glucose(FPG)in early pregnancy and the risk of gestational diabetes mellitus(GDM).Methods:A retrospective analysis was conducted on the ear-ly pregnancy clinical data of 1044 singleton pregnant women who delivered between June 1,2017 and December 31,2017 in Beijing Obstetrics and Gynecology Hospital,Capital Medical University.According to whether diag-nosed with GDM or not,they were divided into GDM group(n=173)and non GDM group(n=871).Univariate and multivariate regression analyses were used to examine the association of FPG in the first trimester with GDM occurrence.Results:Among the1044 pregnant women in the study,173(16.6% )were diagnosed with GDM.The age,pre pregnancy BMI,and early pregnancy FPG of the GDM group were significantly higher than those of the non GDM group,and the differences were statistically significant(P<0.05).After adjusting for age,pre-pregnan-cy BMI and blood lipid index,the results of multivariate Logistic regression analysis showed that FPG in the first trimester was an independent risk factor for GDM occurrence(OR>1,P<0.05).Using FPG<5.1 mmol/L as a reference,when FPG≥5.1 mmol/L,the risk of GDM occurrence increased by 3.26 times(OR 3.26,95% CI 2.20-4.84,P<0.001).Conclusions:FPG in the first trimester is an independent risk factor for the occurrence of GDM.The increase of FPG level in the first trimester is significantly correlated with the occurrence of GDM.
国家科技期刊平台
NSTL
万方数据
