术前血清雌二醇水平与中-重度宫腔粘连术后妊娠结局的相关性分析
Correlation Analysis between Preoperative Serum Estradiol Levels and Postop-erative Pregnancy Outcomes in Patients with Moderate-to-Severe Intrauterine Adhesion
张琬琳 1邱丹儿 1汤若楠 1肖西峰 1王晓红1
作者信息
- 1. 空军军医大学第二附属医院 唐都医院妇产科生殖医学中心,陕西 西安 710000
- 折叠
摘要
目的:探讨宫腔镜下粘连分离术(TCRA)前1d的血清雌二醇(E2)水平与中-重度宫腔粘连(IUA)妊娠结局之间的关系.方法:提取并分析了2018 年1 月至2019 年12 月于空军军医大学第二附属医院确诊并接受TCRA的中-重度IUA患者的临床数据.主要结局指标是12 个月随访期间的妊娠率,应用多元回归分析、平滑曲线拟合和递归算法分析.结果:在符合纳入标准的288 例患者中,有222 例符合标准,并最终被纳入分析.多元回归分析结果显示,术前1d的E2水平与TCRA后的妊娠率呈负相关(aOR 0.77,95%CI 0.63～0.93,P=0.0074).递归算法分析结果显示,当术前血清E2水平小于 380.6 pmol/L时,每增加 36.7 pmol/L,妊娠率就会降低约 20%(aOR 0.78,95%CI 0.67～0.89,P=0.0004).结论:术前血清E2水平与中-重度IUA患者的妊娠结局呈负相关.
Abstract
Objective:To investigate the relationship between serum estradiol(E2)levels on the day before transcervical resection of adhesion(TCRA)and pregnancy outcomes in moderate-severe intrauterine adhesion(IUA).Methods:Clinical data of patients with moderate-severe IUA diagnosed and received TCRA in the Second Affiliated Hospital of Air Force Medical University from January 2018 to December 2019 were extracted and ana-lyzed.The primary outcome indicator was the pregnancy rate during the 12-month follow-up period.Multiple re-gression analysis,smoothed curve fitting and recursive algorithm analysis were applied in this study.Results:A-mong the 288 patients who met the inclusion criteria,222 met the criteria and were finally included in the analysis.The results of multiple regression analysis showed that the E 2 level on the day before surgery was negatively cor-related with the pregnancy rate after TCRA(aOR 0.77,95% CI 0.63-0.93,P=0.0074).Recursive algorithm a-nalysis showed that when the preoperative serum E2 level was less than 380.6 pmol/L,for every increase of 36.7 pmol/L pregnancy rate decreased by approximately 20% (aOR 0.78,95% CI 0.67-0.89,P=0.0004).Conclusions:The results suggest that preoperative serum E2 levels are negatively associated with pregnancy outcomes in patients with moderate-to-severe IUA.
关键词
宫腔镜下宫腔粘连分离术/雌激素/子宫内膜修复Key words
Transcervical resection of adhesion/Estrogen/Endometrial repair引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据