A Study on Disease Burden of Endometriosis in China from 1990 to 2019 Based on Age-Period-Cohort Model
Objective:To explore the effects of age,period and cohort on the incidence of endometriosis(EMT)and disability adjusted life year(DALY)in China from 1990 to 2019.Methods:Using the Global Burden of Disease(GBD)2019 database,the incidence of EMT and DALY in China from 1990 to 2019 were analyzed.The time variation trend of standardized incidence and standardized DALY rate was analyzed with Joinpoint 4.8.0.1 software,and the average annual percentage change was calculated.The age-period-cohort model was construc-ted to analyze the effect of age,period and birth cohort on the incidence of endometriosis and DALY trend change.Results:In 2019,the incidence of EMT in China was 72.61/100,000,and the DALY rate was 47.38/100,000.The incidence rate and DALY rate were 39.71％and 24.97％lower than those in 1990.From 1990 to 2019,the standardized incidence rate and standardized DALY rate of EMT in China showed a downward trend,with an an-nual decrease of 1.02％and 1.00％respectively,with statistical significance(P＜0.05).The results of age effect showed that the overall incidence of EMT in China showed was decreasing,and the DALY rate was increasing from 15 to 29 years old,and then decreased after 30 years old.The results of period effect showed that the relative ratio(RR)of EMT incidence risk and DALY risk in China showed a decreasing trend.Taking the period from 2000 to 2004 as the reference group,the incidence risk(RR 1.78,95％CI 1.64-1.95)and DALY risk(RR 1.05,95％CI 0.90-1.23)were the highest in 1990-1994.The results of cohort effect showed that the later people were born,the lower the risk of EMT was.Conclusions:From 1990 to 2019,the standardized incidence rate and standardized DALY rate of EMT in China showed a downward trend.The epidemiological patterns and trends of EMT in differ-ent ages,periods and birth cohorts may provide new insights for public health,and provide an important basis for formulating public health strategies to further reduce the burden of EMT.
EndometriosisChinaAge-period-queue modelIncidenceDisability adjusted life year
万方数据
维普
