Changes of serum and placental levels of Gal-3 and Gal-9 in pregnant women with early-onset and late-onset preeclampsia and their clinical significance
Objective To study the expression levels of galectin-3(Gal-3)and galectin-9(Gal-9)in serum and placenta of pregnant women with early preeclampsia(EOPE)and late preeclampsia(LOPE)and their clinical significance.Methods 30 pregnant women with EOPE were selected as EOPE group and 50 pregnant women with LOPE were selected as LOPE group.Another 40 healthy pregnant women were randomly selected as control group.The expressions of Gal-3 and Gal-9 in serum and placenta were compared among the three groups.Results The expression levels of Gal-3 and Gal-9 in serum and placenta of EOPE group and LOPE group were significantly higher than those of control group(P＜0.05),and the expression levels of Gal-3 and Gal-9 in serum and placenta of EOPE group were higher than those of LOPE group(P＜0.05).Conclusion Gal-3 and Gal-9 may be related to the occurrence and development of PE,so as to help understand the pathogenesis and clinical diagnosis and treatment of PE.
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