Analysis of HPV genotypes and risk factors in 1914 female physical examinations
Objective To investigate the infection status,genotype distribution and risk factors of cervical human papillomavirus(HPV)in female physical examiners.Methods In 1914,physical examiners who underwent HPV 23 typing test for cervical exfoliated cells were selected as the research objects,and the HPV typing in cervical exfoliated cells was detected by nid-based PCR and pyrosequencing technology.General information,menstrual status,marital and reproductive history and reproductive tract disease history of all subjects were collected and analyzed statistically.The risk factors of HPV infection were analyzed.Results Among the 1914 subjects,HPV positive subjects accounted for 9.82％(188/1914).The HR-HPV types were 16.The highest detection rate was HPV53,accounting for 15.96％(30/188),followed by HPV52,accounting for 15.43％(29/188).Univariate analysis showed that drinking alcohol,sexual partner＞1,sexual frequency＞4 times/month,accompanied by cervical erosion were the factors of HPV infection(P＜0.05).Logistic regression analysis showed that drinking alcohol,sexual partner＞1,sexual frequency＞4 times/month,accompanied by cervical erosion were independent factors of HPV infection(P＜0.05).Conclusion HPV DNA genotype detection can provide the basis for the development of HPV vaccine and the early screening of cervical cancer,and help high-risk groups to prevent,diagnose and treat early.
Cervical human papillomavirusCervical tumorGenotypeRisk factor
万方数据
维普
