Comparative analysis of the efficacy of different doses of Mifepristone combined with misoprostol and estradiol valerate in the treatment of missed abortion
Objective To analyze the clinical effect of different doses of mifepristone combined with misoprostol and estradiol valerate in the treatment of missed abortion.Methods 80 missed abortion patients were selected and divided into high-dose group(treated with 200 mg mifepristone+estradiol valerate+misoprostol)and low-dose group(treated with 150 mg mifepristone+estradiol valerate+misoprostol)according to random drawing method,with 40 cases in each group.The clinical time index,total abortion rate and adverse drug reactions were compared between the two groups.Results There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The total abortion rate in the high-dose group was 97.50％higher than that in the low-dose group(80.00％),and the difference was statistically significant(P＜0.05).The embryo outflow time and menstrual rehydration time in the high-dose group were significantly shorter than those in the low-dose group,and the difference was statistically significant(P＜0.05).Conclusion The combination of large-dose mifepristone with estradiol valerate and misoprostol in the treatment of missed abortion is safe and time-effective.
万方数据
维普
