Application and clinical significance of molecular subtyping in endometrial cancer
Objective To analyze the application and clinical significance of molecular typing in endometrial cancer.Methods 40 patients with endometrial cancer in our hospital were selected as the research subjects.Perform routine pathological and immunohistochemical staining sections on it to analyze the distribution of molecular subtypes.Among the 40 patients,11,20,7,and 2 were high copy type,low copy type,MSI-H type,and POLE super mutation type,respectively.Results Among them,there were a total of 33 cases of endometrioid adenocarcinoma,while 6,19,6,and 2 were high copy type,low copy type,MSI-H type,and POLE super mutation type,respectively.There are a total of 7 cases of non-endometrial adenocarcinoma,including 5 cases of low copy type,1 case of MSI-H type,and 1 case of POLE super mutation type.There were statistically significant differences in molecular subtype p53 status,MMR protein expression,lymph node metastasis,vascular infiltration,FIGO staging,tumor pathological type,and family history of malignant tumors among 40 patients(P＜0.05).During the 3-year follow-up period,there were no patient deaths,with a total of 11 relapses and a recurrence rate of 22.50％.The recurrence rates for high copy,low copy,and MSI-H types were 55.56％,22.22％,and 22.22％,respectively.In the distribution of progression free survival rate,the high copy type was 52.50％,the low copy type was 92.50％,the MSI-H type was 77.50％,and the POLE super mutant type was 100％.Conclusion Molecular subtyping of endometrial cancer can provide reference for prognosis and treatment,ensuring that patients receive more effective treatment,and is worthy of clinical application.
Endometrial cancerMolecular typingHigh copy typeLow copy type
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