Comparative study of intrathecal injection of three opioid drugs with compound adjusted dose bupivacaine for cesarean section
Objective Compare the effects of three opioid drugs combined with adjusted doses of bupivacaine as a spinal anesthetic for cesarean section,and evaluate the perioperative anesthesia and adverse reactions.Methods 90 patients of single full-term pregnancy who underwent elective or emergency cesarean section surgery were selected and randomly divided into M group(n=28),F group(n=30),and S group(n=29)using a random number table method.Morphine 200,Fentanyl 16μg and sufentanil 2 μg was injected into each group.Adjust the dosage of 0.5％bupivacaine for spinal anesthesia according to the height and body weight of the mother.Observe the anesthesia effect and adverse reactions during surgery,and conduct statistical analysis.Results Collect 87 valid research samples.The time for the S group to reach the T6 level of sensory blockade was shorter than that of the F and M groups,and the complete and effective pain relief time of the M group was longer than that of the S and F groups,with statistical significance(P＜0.05).The R value of muscle relaxation rating in Group M was greater than the mean rating of Group 3,and the difference was statistically significant(P＜0.05).The incidence of nausea in group M was higher than that in groups F and S,and the difference was statistically significant(P＜0.05).Conclusion Intrathecal injection of three opioid drugs combined with adjusted dose bupivacaine for cesarean section can provide satisfactory anesthesia effects during the perioperative period,with fewer adverse reactions in newborns.Considering factors such as slower onset time and unknown delayed postoperative complications,intrathecal injection of sufentanil is more advisable.
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