Value analysis of HPV combined with tumor marker examination in the diagnosis of ovarian cancer
Objective To explore the value of human papillomavirus(HPV)combined with tumor marker testing in the diagnosis of ovarian cancer.Methods Retrospective analysis of clinical data from 80 highly suspected ovarian cancer patients.According to pathological diagnosis,they were divided into ovarian cancer group(47 cases)and benign tumor group(33 cases).Compare the results of two sets of HPV tests and tumor marker tests,draw ROC curves,and compare the sensitivity and specificity of different examination methods in the diagnosis of ovarian cancer.Results The positive rates of serum carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),cytokeratin 19 fragment(CYFRA 21-1),and HPV in the ovarian cancer group were higher than those in the benign tumor group,and the differences were statistically significant(P＜0.05).According to ROC curve analysis,the value of HPV combined with tumor markers in the diagnosis of ovarian cancer is higher than that of CA125,CA199,CYFRA 21-1,HPV examination,and tumor markers,and the difference is statistically significant(P＜0.05).Conclusion HPV examination,tumor marker examination,and their combination have diagnostic value for ovarian cancer,but the sensitivity and specificity of HPV combined with tumor marker examination are higher,which can further improve diagnostic efficiency.
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