Value analysis of NT ultrasound combined with non-invasive DNA testing for prenatal screening of elderly pregnant women
Objective To explore the application value of fetal nuchal translucency(NT)ultrasound combined with non-invasive DNA testing for prenatal screening in elderly pregnant women.Methods Clinical data of 486 elderly single pregnancy women who underwent prenatal examination and delivery in our hospital were selected.According to the different prenatal screening methods chosen by pregnant women,they were divided into NT group(n=127 cases)and combination group(n=359 cases).The NT group used NT ultrasound detection,while the combined group used NT ultrasound detection combined with non-invasive DNA testing to compare the detection rate and missed diagnosis rate of fetal chromosomal diseases between the two groups.Results Based on the amniocentesis test results as the gold standard,the detection rate of fetal chromosomal diseases in the NT group was 66.67％,and the detection rate of fetal chromosomal diseases in the combination group was 80.00％.The detection rate in the combination group was higher than that in the NT group;The missed diagnosis rate in the NT group was 33.33％,while the missed diagnosis rate in the combination group was 20.00％.The missed diagnosis rate in the combination group was lower than that in the NT group.Conclusion NT ultrasound combined with non-invasive DNA testing is effective for prenatal screening of elderly pregnant women.The detection rate of fetal chromosomal diseases is high,and the missed diagnosis rate is low.
NT ultrasound testingNon invasive DNA testingPregnant woman in elder age
NETL
NSTL
万方数据
