Effects of vitamin D assisted low molecular weight heparin calcium on coagulation function,lipid metabolism and pregnancy outcome in patients with preeclampsia
Objective To investigate the effects of vitamin D assisted low molecular weight heparin calcium on coagulation function,lipid metabolism and pregnancy outcome in patients with preeclampsia.Methods A total of 52 cases of preeclampsia patients were randomly divided into control group and study group by coin toss,with 26 cases in each group.The control group was treated with low molecular weight heparin calcium,and the study group was supplemented with vitamin D.The coagulation function,lipid index and pregnancy outcome of the two groups were compared.Results Before treatment,there were no significant differences in the levels of fibrinogen(FIB),activated partial thromboplastin time(APTT),prothrombin time(PT)and serum thromboplastin time(TT)between 2 groups(P＞0.05).After treatment,the levels of FIB,APTT,PT and TT in both groups were better than before treatment,and the study group was better than the control group(P＜0.05).Before treatment,there were no significant differences in the levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)between two groups(P＞0.05).After treatment,the levels of TC,TG,HDL-C and LDL-C in the study group were better than before treatment,and the study group was better than the control group(P＜0.05).There was no significant difference in the incidence of HELLP syndrome and renal insufficiency between the two groups(P＞0.05).The incidence of placental abruption in the study group was lower than that in the control group,and the improvement rate of conscious symptoms in pregnant women was higher than that in the control group(P＜0.05).Conclusion The treatment of preeclampsia with vitamin D assisted low molecular weight heparin calcium has a good effect,which can effectively improve the coagulation function and lipid metabolism of patients,reduce the incidence of adverse pregnancy outcomes,and is worthy of clinical promotion and application.
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