Effects of low molecular weight heparin combined with aspirin on coagulation function,uterine artery flow and pregnancy outcome in patients with hypertensive diseases during pregnancy
Objective To investigate the effects of low molecular weight heparin combined with aspirin on coagulation function,uterine artery flow and pregnancy outcome in patients with hypertensive diseases during pregnancy.Methods 60 patients with hypertensive diseases during pregnancy were randomly divided into a study group and a control group,with 30 cases in each group.The control group was treated with low molecular weight heparin,and the study group was treated with low molecular weight heparin combined with aspirin.The coagulation function,uterine blood flow indexes and the incidence of adverse pregnancy outcome were compared between the two groups.Results After treatment,the level of D-2 polymer in the study group was lower than that in the control group(P＜0.05).After treatment,the resistance index,the pulse index of external iliac artery and the umbilical arterial S/D ratio in the study group were higher than those in the control group(P＜0.05).The incidence of adverse pregnancy outcome in the study group was 6.67％,which was significantly lower than 26.67％in the control group(P＜0.05).Conclusion Low molecular weight heparin combined with aspirin in the treatment of hypertensive diseases during pregnancy can effectively reduce the D-2 polymer level,stabilize the uterine artery blood flow and improve the pregnancy outcome.
Low molecular weight heparinAspirinHypertensive disorders during pregnancy
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