Effect of tranexamic acid combined with oxytocin on preventing postpartum hemorrhage after cesarean section and the influence on coagulation function of parturients
Objective To evaluate the effect of tranexamic acid combined with oxytocin on reducing blood loss after cesarean section.Methods 96 parturients who underwent cesarean section were selected as the research objects and were randomly divided into a control group and a study group,with 48 cases in each group.After delivery,the control group received oxytocin,and the study group received tranexamic acid on the basis of the control group.The blood loss,coagulation indexes and incidence of adverse reactions were compared between the two groups in different time periods.Results The blood loss at 1 and 24 h after surgery in the study group were(226.92±51.65)ml and(319.54±73.82)ml,respectively,which were lower than(336.37±54.79)ml and(437.86±78.61)ml in the control group(P＜0.05).The levels of prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)in both groups were improved 24 h after surgery,and the levels of PT and APTT in the study group were lower than those in the control group,while the level of FIB was higher than that in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application of tranexamic acid combined with oxytocin after cesarean section can effectively reduce the amount of maternal blood loss,improve the coagulation indexes,increase the FIB level,and does not increase the incidence of adverse reactions,showing good clinical application value.
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