To investigate the value of HPV E6/E7mRNA detection combined with photodynamic therapy in the shunt diagnosis and treatment of patients with low-grade squamous intraepithelial lesions of the cervix
Objective To investigate the value of HPV E6/E7mRNA detection combined with photodynamic therapy in the shunt diagnosis and treatment of low-grade squamous intraepithelial lesions(LSIL).Methods 100 female LSIL patients were selected for HPV typing and E6/E7mRNA detection,and then provided with photodynamic therapy.The clinical effect and HPV negative conversion were compared at different time after treatment.Results The diagnostic accuracy of HPV typing and E6/E7mRNA were 90.0％and 88.0％respectively.After 6 months of treatment,the total effective rate and HPV negative conversion rate were 91.0％and 62.0％,which were higher than 71.0％and 42.0％after 3 months of treatment,and the differences were statistically significant(P＜0.05).Conclusion The combined application of HPV E6/E7mRNA assay has high accuracy in determining LSIL.And to provide patients with photodynamic therapy,the effect is remarkable,can significantly improve the symptoms,promote the rapid recovery of the condition.
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