反复胚胎种植失败行PGT-A妇女的临床特点分析
The clinical characteristics of PGT-A women with repeated embryo implantation failure were analyzed
李为玉 1周欣 1段金良1
作者信息
- 1. 中国人民解放军联勤保障部队第九二四医院生殖中心,广西桂林 541002
- 折叠
摘要
目的 分析反复胚胎种植失败妇女行植入前遗传学筛查(PGT-A)技术的临床特点.方法 选取498例体外受精-胚胎移植治疗的不孕症妇女,其中反复种植失败(RIF)行PGT-A妇女79例(RIF组),对照组419例.根据是否获得整倍体胚胎将79例RIF患者分为获得整倍体胚胎组51例(RIF-S)和未获得组28例(RIF-F).观察其临床特点.结果 RIF组年龄大于对照组,基础卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平均高于对照组,基础窦卵泡计数(AFC)少于对照组,外源性促性腺激素(Gn)用量、人绒毛膜促性腺激素(HCG)日E2水平、获卵数、MII卵数、2PN数均低于对照组(P＜0.05).RIF-S组年龄小于RIF-F组,活检胚胎数、D3优胚数、囊胚数、优囊数均多于RIF-F组(P＜0.05).结论 高龄及卵巢储备功能差的女性容易发生RIF.
Abstract
Objective To analyze the clinical characteristics of preimplantation genetic screening(PGT-A)in women with repeated failed embryo implantation.Methods 498 infertile women receiving IVF and embryo transfer treatment were selected,including 79 women receiving PGT-A after repeated implantation failure(RIF group)and 419 women in the control group.According to whether euploid embryos were obtained or not,79 RIF patients were divided into euploid embryo group(51 cases)and not(28 cases).Results The age of RIF group was longer than that of control group,the levels of basal follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E,)were higher than those of control group,and the basal sinus follicle count(AFC)was lower than that of control group.Exogenous gonadotropin(Gn)dosage,human chorionic gonadotropin(HCG)day E2 level,egg number,MII egg number and 2PN number were all lower than those in control group(P＜0.05).The age of RIF-S group was lower than that of RIF-F group,and the number of biopsy embryos,D3 fine embryos,blastocysts and fine capsules were higher than those of RIF-F group(P＜0.05).Conclusion RIF is more likely to occur in elderly women with poor ovarian reserve.
关键词
反复胚胎种植失败/胚胎植入前遗传学筛查/胚胎非整倍性Key words
Repeated embryo implantation failure/Preimplantation genetic screening/Fetal aneuploidy引用本文复制引用
基金项目
广西卫生健康委自筹经费科研课题(Z-C20221053)
出版年
2024
NETL
NSTL
万方数据