首页|血清CA153、CA125、HE4水平联合检测在妇科恶性肿瘤诊断中的应用价值分析

血清CA153、CA125、HE4水平联合检测在妇科恶性肿瘤诊断中的应用价值分析

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目的 探讨血清糖类抗原153(CA153)、糖类抗原125(CA125)、人附睾蛋白4(HE4)水平联合检测在妇科恶性肿瘤诊断中的应用价值.方法 选取62例经术后病理报告确诊的妇科恶性肿瘤患者作为研究组,同期60例妇科体检健康女性作为对照组,同期60例妇科良性病变患者作为良性病变组.检测对比三组血清CA153、CA125、HE4水平以及单项与联合阳性检出率.结果 良性病变组血清CA153、CA125、HE4水平均高于对照组,且均低于研究组(P<0.05);研究组、良性病变组血清CA153、CA125阳性检出率均高于对照组(P<0.05);良性病变组血清HE4阳性检出率、三项指标联合阳性检出率均高于对照组,且均低于研究组(P<0.05).结论 在妇科恶性肿瘤诊断中,HE4具有较高的敏感度与特异度,HE4联合CA153、CA125水平联合检测可在一定程度上提高诊断准确率.
Analysis of the application value of combined detection of serum CA153,CA125,and HE4 levels in the diagnosis of gynecological malignant tumors
Objective To investigate the value of combined detection of serum carbohydrate antigen 153(CA153),carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)in the diagnosis of gynecological malignant tumors.Methods 62 patients with gynecological malignant tumor confirmed by pathological report after surgery as a study group,60 healthy women with gynecological physical examination during the same period as the control group,and 60 patients with gynecological benign lesions during the same period as the benign lesion group were selected.Serum CA153,CA125,HE4 levels and single and combined positive detection rates were detected and compared among the three groups.Results The levels of serum CA153,CA125 and HE4 in benign lesion group were higher than those in control group,and lower than those in study group(P<0.05).The positive rates of CA153 and CA125 in the study group and the benign lesion group were higher than those in the control group(P<0.05).The positive detection rate of serum HE4 in benign lesion group and the combined positive detection rate of three indexes were higher than those in control group,and lower than those in study group(P<0.05).Conclusion HE4 has high sensitivity and specificity in the diagnosis of gynecological malignant tumors,and the combined detection of HE4 with CA153 and CA125 levels can provide diagnostic accuracy to a certain extent.

Serum carbohydrate antigen 153Carbohydrate antigen 125Human epididymal protein 4Joint detectionGynecological malignant tumor

周瑜、王琪

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南通市第六人民医院检验科,江苏 南通 226000

无锡市第五人民医院检验科,江苏无锡 214000

血清糖类抗原153 糖类抗原125 人附睾蛋白4 联合检测 妇科恶性肿瘤

2024

实用妇科内分泌电子杂志

实用妇科内分泌电子杂志

ISSN:
年,卷(期):2024.11(8)
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