白蛋白结合型紫杉醇联合顺铂治疗中晚期宫颈癌的效果分析
Effect analysis of albumin-bound paclitaxel combined with cisplatin in the treatment of advanced cervical cancer
陈坤燕 1顾欣欣2
作者信息
- 1. 南通大学附属启东医院/启东市人民医院/启东肝癌防治研究所 肿瘤内科,江苏 南通 226200
- 2. 南通大学附属启东医院/启东市人民医院/启东肝癌防治研究所 妇科,江苏 南通 226200
- 折叠
摘要
目的 探讨晚期宫颈癌采用白蛋白结合型紫杉醇联合顺铂的治疗效果.方法 选择98例中晚期宫颈癌患者为研究对象,根据随机数字表法分为研究组和对照组,每组49例.对照组采用紫杉醇结合顺铂治疗,研究组采用白蛋白结合型紫杉醇联合顺铂治疗,比较两组血清肿瘤标志物水平、治疗效果及不良反应.结果 治疗前,两组鳞状上皮细胞癌抗原(SCCA)、细胞角蛋白19的可溶性片段(CYFRA21-1)水平比较,差异均无统计学意义(P＞0.05);治疗后,研究组SCCA、CYFRA21-1水平均低于对照组(P＜0.05);研究组治疗总有效率高于对照组(P＜0.05);研究组不良反应发生率低于对照组(P＜0.05).结论 中晚期宫颈癌采用白蛋白结合型紫杉醇联合顺铂的治疗效果较好,可降低血清肿瘤标志物水平,减少不良反应发生率,值得临床推广与应用.
Abstract
Objective To investigate the effect of albumin-bound paclitaxel combined with cisplatin in the treatment of advanced cervical cancer.Methods A total of 98 patients with advanced cervical cancer were selected as the study objects and divided into study group and control group according to random number table method,49 cases in each group.The control group was treated with paclitaxel combined with cisplatin,and the study group was treated with albumin-bound paclitaxel combined with cisplatin.Serum tumor marker levels,therapeutic efficacy and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in the levels of squamous cell carcinoma antigen(SCCA)and cytokeratin-19 soluble fragment(CYFRA21-1)between two groups(P＞0.05).After treatment,the levels of SCCA and CYFRA21-1 in study group were lower than those in control group(P＜0.05).The total effective rate of the study group was higher than that of the control group(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).Conclusion The treatment effect of albumin-bound paclitaxel combined with cisplatin is good,which can reduce the level of serum tumor markers and reduce the incidence of adverse reactions,and is worthy of clinical promotion and application.
关键词
宫颈癌/中晚期/白蛋白结合型紫杉醇/顺铂/治疗效果Key words
Cervical cancer/Middle and late stage/Albumin-bound paclitaxel/Cisplatin/Therapeutic effect引用本文复制引用
出版年
2024
NETL
NSTL
万方数据