Study on the correlation between EPHB4 and villus angiogenesis in recurrent abortion
Objective To investigate the relationship between downregulation of EPHB4 in villus tissue and dysangiogenesis in patients with recurrent abortion(RSA).Methods Villus tissue samples from 19 RSA patients(RSA group)and 14 early pregnancy termination patients(NC group)were collected.The expression of EPHB4 was detected by RT-qPCR and Western blotting.The villus microvascular density was calculated by immunohistochemical staining labeled CD31,and the correlation between the two samples was analyzed.Results The expression of EPHB4 and microvascular density in RSA group were lower than those in NC group(P＜0.05).EPHB4 mRNA was moderately positively correlated with villus microvessel density(r=0.4961,P=0.0362).Conclusion The expression of EPHB4 is downregulated in patients with recurrent spontaneous abortion,which may be involved in the occurrence and development of RSA by inhibiting villus angiogenesis.
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