Correlation study of vaginal microenvironment changes with high-risk HPV infection and cervical lesions
Objective To look into the connection between cervical lesions,high-risk human papillomavirus(HR-HPV)infection,and the vaginal microenvironment.Methods 120 patients with cervical lesions were selected as the observation group.Another 120 healthy subjects who underwent physical examination during the same period were selected as the control group.The subjects were tested for vaginal microecological balance,vaginal flora and HR-HPV infection.The vaginal microecological disorder,the detection rate of vaginal flora,the positive rate of HPV and the composition of HPV types were compared and analyzed.Results Compared with the control group,the observation group had higher rates of vaginal microbiota dysbiosis,HPV positivity,detection of lactobacilli,clue cells,and vaginal trichomonas(P＜0.05);Vaginal microecological disorder and HPV positive were positively correlated with cervical disease(r=0.675、0.698,P=0.020、0.016).Conclusion Cervical lesions are closely related to vaginal microecological imbalance and HPV infection.Therefore,strengthening the study of vaginal microecological status and HPV infection status in patients with cervical diseases will provide theoretical basis for clinical formulation of reasonable diagnosis and treatment strategies.
Vaginal microenvironmentHigh-risk human papillomavirusCervical lesions
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