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HPV疫苗接种对育龄期女性HPV感染的预防效果

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目的 探讨人乳头瘤病毒(HPV)疫苗接种对育龄期女性HPV感染的预防效果.方法 选取170例年龄24~50岁育龄期女性作为研究对象,根据是否接种过HPV疫苗分为试验组(接种过HPV疫苗,多为某部队现役人员及家属,生活习惯及受教育程度使得接种意识较高,感染率低)与对照组(未接种过HPV疫苗),各85例.采用实时荧光定量聚合酶链式反应(PCR)技术检测HPV高危型感染情况.比较两组疫苗预防效果、不良情绪及生活质量评分.结果 试验组HPV持续感染、HPV高危型机会性感染、CINⅠ~Ⅱ级感染率(1.18%、2.35%、0)均低于对照组(9.41%、12.94%、7.06%),差异有统计学意义(P<0.05).试验组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组,差异有统计学意义(P<0.05).试验组生活质量评分高于对照组,差异有统计学意义(P<0.05).结论 HPV疫苗接种对育龄期女性HPV感染具有明显预防效果,能显著降低HPV感染率,改善育龄期女性的情绪和生活质量,为育龄期女性群体预防HPV提供新的方案.
The preventive effect of HPV vaccination on HPV infection in women of reproductive age
Objective To investigate the preventive effect of human papillomavirus(HPV)vaccination on HPV infection in women of childbearing age.Methods 170 women aged 24 to 50 years of reproductive age were selected as the research objects.According to whether they had received HPV vaccine,they were divided into the experimental group(vaccinated HPV vaccine,most of them were active personnel and their families in a military unit,living habits and education made vaccination awareness high and infection rate low)and the control group(not vaccinated HPV vaccine),85 cases each.Real-time fluorescence quantitative polymerase chain reaction(PCR)was used to detect high-risk HPV infection.The vaccine preventive effect,adverse mood and quality of life score were compared between the two groups.Results The infection rates(1.18%,2.35%,0)in the experimental group were lower than those in the control group(9.41%,12.94%,7.06%),and the difference was statistically significant(P<0.05).The scores of self-rating anxiety scale(SAS)and self-rating depression scale(SDS)in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).The quality of life score of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion HPV vaccination has obvious preventive effect on HPV infection in women of childbearing age,can significantly reduce HPV infection rate,improve the mood and quality of life of women of childbearing age,and provide a new program for the prevention of HPV in women of childbearing age.

HPV vaccinationWomen of childbearing agePreventive effect

王静、向磊、郝瑞峰、陈强

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中国人民解放军63710部队医院 检验病理科,山西 忻州 036300

HPV疫苗接种 育龄期女性 预防效果

2024

实用妇科内分泌电子杂志

实用妇科内分泌电子杂志

ISSN:
年,卷(期):2024.11(12)