Effect of pregnancy outcome in hypothyroidism during pregnancy and evaluation of the therapeutic value of levothyroxine sodium tablets
Objective To observe the effect of hypothyroidism(hypothyroidism)on pregnancy outcome and evaluate the clinical value of levothyroxine sodium tablets.Methods 119 pregnant women were selected as the normal group according to 1:1 ratio.The pregnant women with hypothyroidism were treated with levothyroxine sodium tablets and the therapeutic effect was observed.Results Among 119 pregnant women with hypothyroidism,78 had TSH＜2.5 mIU/L before delivery(observation group),and 41 had TSH＞2.5 mIU/L(control group).The adverse outcomes of pregnancy and perinatal infants were compared among the three groups,and the difference was statistically significant(P＜0.05).The incidence of adverse pregnancy outcomes in control group was 48.78％and the incidence of perinatal adverse outcomes in control group was 26.83％,which were higher than those in observation group(16.67％and 10.26％,respectively)(P＜0.05).There was no significant difference in the incidence of adverse outcomes and perinatal adverse outcomes between the normal group and the observation group(P＞0.05).Conclusion Hypothyroidism during pregnancy has a great impact on maternal and infant outcomes.Screening of thyroid function indicators should be carried out early,monitoring should be intensified,and levothyroxine sodium tablets should be taken as soon as possible to reduce the corresponding risk.
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