Application of interferon-a2b and antifungal drugs combined with Lactobacillus capsules in the treatment of recurrent vulvovaginal candidiasis
Objective To explore the application of interferon-α2b and antifungal drugs combined with Lactobacillus capsules in the treatment of recurrent vulvovaginal candidiasis(RVVC).Methods 100 patients with recurrent vulvovaginal candidiasis(RVVC)with fungal culture results of Candida alba were selected and divided into combined treatment group 1 and combined treatment group 2 with 50 cases in each group by random number table method.Group 1 received fluconazole shock therapy and clotrimazole vaginal tablets for 6 months.In combination group 2,Lactobacillus capsules and interferon α2b vaginal effervescent tablets were added to combination group 1 for 6 months.Every month,the patients went to the hospital for gynecological examination and vaginal secretion microecological detection,and compared the treatment effect of the two groups.Results After 6 months of treatment,compared with the combined treatment group 1,the positive rate of candida alba culture,clinical symptom score,gram-positive coccus,Campylobacter and candida alba mycelium detection and bacterial population density decreased in the combined treatment group 2,while the cleanliness of leucorrhea,lactobacillus proportion,bacterial diversity,H2O2 content,Nugent score and AV score increased in the combined treatment group 2.The proportion of patients with negative leucocyte esterase and sialoglycosidase and vaginal microecological balance increased,and the recurrence rate of combined treatment group 1 was higher than that of combined treatment group 2 during treatment or within 3 months(P＜0.05).There were significant differences between the two groups in the effective rate and the cure rate after 3 to 6 months of discontinuation(P＜0.05).Conclusion The combination of interferon-α2b and azole antifungal drugs with Lactobacillus capsules can promote the recovery of vaginal microecological environment in patients with RVVC,the treatment of RVVC is effective,which is worthy of further promotion and application.
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