Exploration of optimal serum biomarkers for predicting the occurrence and severity of preeclampsia
Objective To explore the optimal biomarker indicators for predicting the occurrence and severity of preeclampsia.Methods 30 pre eclampsia pregnant women were selected as the experimental group,and 90 normal pregnant women during the same period were selected as the control group.Collect general information of the research subjects,collect fasting venous blood from 10～14 weeks of pregnancy,detect serum levels of placental growth factor(PLGF),soluble vascular endothelial growth factor receptor-1(sFlt-1),advanced protein oxidation products(AOPPs),malondialdehyde(MDA),and total antioxidant capacity(T-AOC),and analyze the optimal serum biomarkers for predicting preeclampsia.Results The serum levels of PLGF and T-AOC in the experimental group were lower than those in the control group,while the levels of sFlt-1,AOPPs,and MDA were higher than those in the control group(P＜0.05);SFlt-1 is the optimal indicator for predicting preeclampsia,with a sensitivity of 90.24％and a 95％CI(0.901,0.946).Combined detection of various indicators can improve diagnostic efficiency.Conclusion For preeclampsia,serum biomarkers can predict disease occurrence and evaluate the severity of the condition in the early stage,with sFlt-1 being the optimal indicator,and the combined indicator has a better predictive effect.
PreeclampsiaBiomarkersDegree of illnessPrediction effect
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NSTL
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