The expression levels of Notch transmembrane receptor-1 and hypoxia-inducible factor-la in endometrium of patients with uterine adhesion were analyzed
Objective The expression levels of Notch transmembrane receptor-1(Notch1)and hypoxia-inducible factor-1α(HIF-1α)in endometrium of patients with uterine adhesion were analyzed.Methods 37 patients with non-uterine adhesion were selected as control group,and 75 patients with uterine adhesion were selected as intrauterine adhesion group.The mRNA expression levels of Notch1 and HIF-1α in uterine tissue of the two groups were detected and compared,and the mRNA expression levels and protein expression levels of Notch1 and HIF-1α in uterine adhesion groups with different degrees of severity were compared,and the correlation between the expression levels of Notch1 and HIF-1α and the severity of cervical adhesion was analyzed.Results Compared with control group,Notch1 mRNA and HIF-1α mRNA in intrauterine adhesion group were significantly higher,and the difference was statistically significant(P＜0.05).The mRNA and protein expression levels of Notch1 and HIF-1α in severe group were higher than those in moderate group and mild group(P＜0.05),and the mRNA and protein expression levels of Notch1 and HIF-1α in moderate group were higher than those in mild group(P＜0.05).The expression levels of Notch1 and HIF-1α were positively correlated with the severity of intrauterine adhesion(P＜0.05).Conclusion The expression levels of Notch1 and HIF-1α in endometrium of patients with intrauterine adhesion were relatively high,and the expression levels of Notch1 and HIF-1α were positively correlated with the severity of intrauterine adhesion.
Intrauterine adhesionNotch transmembrane receptor-1Hypoxia-inducible factor-1 αThe severity of the illnessDisease diagnosis
NETL
NSTL
万方数据
