分析宫腔粘连患者子宫内膜中Notch跨膜受体-1及缺氧诱导因子-1α表达水平
The expression levels of Notch transmembrane receptor-1 and hypoxia-inducible factor-la in endometrium of patients with uterine adhesion were analyzed
涂丽芳 1汪洁 1王翔 1吴霞 1周智俊1
作者信息
- 1. 深圳市光明区妇幼保健院 妇科,广东 深圳 518107
- 折叠
摘要
目的 分析宫腔粘连患者子宫内膜中Notch跨膜受体-1(Notch1)及缺氧诱导因子-1α(HIF-1α)表达水平.方法 选取37例非宫腔粘连患者作为对照组,75例宫腔粘连患者作为宫腔粘连组.比较两组患者宫腔组织中Notch1及HIF-1αmRNA表达水平,比较不同严重程度宫腔粘连组患者Notch1、HIF-1α mRNA表达水平及蛋白表达水平,分析Notch1、HIF-1α表达水平与宫颈粘连严重程度相关性.结果 相比对照组,宫腔粘连组Notch1 mRNA及HIF-1α mRNA均显著更高,差异有统计学意义(P＜0.05).重度组患者Notch1、HIF-1α mRNA及蛋白表达水平高于中度组及轻度组(P＜0.05),中度组患者Notch1、HIF-1α mRNA表达水平及蛋白表达水平均高于轻度组(P＜0.05).Notch1及HIF-1α表达水平与宫腔粘连严重程度成正相关(P＜0.05).结论 宫腔粘连患者子宫内膜中Notch1及HIF-1α有着相对较高的表达水平,Notch1、HIF-1α表达水平与宫腔粘连严重程度成正相关.
Abstract
Objective The expression levels of Notch transmembrane receptor-1(Notch1)and hypoxia-inducible factor-1α(HIF-1α)in endometrium of patients with uterine adhesion were analyzed.Methods 37 patients with non-uterine adhesion were selected as control group,and 75 patients with uterine adhesion were selected as intrauterine adhesion group.The mRNA expression levels of Notch1 and HIF-1α in uterine tissue of the two groups were detected and compared,and the mRNA expression levels and protein expression levels of Notch1 and HIF-1α in uterine adhesion groups with different degrees of severity were compared,and the correlation between the expression levels of Notch1 and HIF-1α and the severity of cervical adhesion was analyzed.Results Compared with control group,Notch1 mRNA and HIF-1α mRNA in intrauterine adhesion group were significantly higher,and the difference was statistically significant(P＜0.05).The mRNA and protein expression levels of Notch1 and HIF-1α in severe group were higher than those in moderate group and mild group(P＜0.05),and the mRNA and protein expression levels of Notch1 and HIF-1α in moderate group were higher than those in mild group(P＜0.05).The expression levels of Notch1 and HIF-1α were positively correlated with the severity of intrauterine adhesion(P＜0.05).Conclusion The expression levels of Notch1 and HIF-1α in endometrium of patients with intrauterine adhesion were relatively high,and the expression levels of Notch1 and HIF-1α were positively correlated with the severity of intrauterine adhesion.
关键词
宫腔粘连/Notch跨膜受体-1/缺氧诱导因子-1α/病情严重程度/疾病诊断Key words
Intrauterine adhesion/Notch transmembrane receptor-1/Hypoxia-inducible factor-1 α/The severity of the illness/Disease diagnosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据