Efficacy and safety assessment of vaginal placement of lactic acid bacteria in the treatment of cervical HPV infection:a systematic review and meta-analysis study
Objective To evaluate the efficacy and safety of lactic acid bacteria in the treatment of cervical human papillomavirus(HPV)infection.Methods The search term"lactic acid bacteria,HPV infection"was used to search PubMed,The Cochrane Library,Web of Science,WanFang Data,CBM,CNKI and VIP databases,and the search time was from the establishment of all major databases to September 17,2023.The two researchers separately screened the literature,extracted data,and assessed the risk of bias.Results A total of 1085 articles were obtained,and 46 articles were included.The results of meta-analysis showed:The effective rate of the lactobacillus group in the treatment of cervical HPV infection was 1.24 times that of the control group[95％CI(1.21,1.27),P＜0.05],and the negative conversion rate was 1.37 times that of the control group[95％CI(1.30,1.44),P＜0.05].Nugent score,vaginal pH and interleukin(IL)-4 decreased significantly compared with the control group(P＜0.05),and IL-12 and interferon-γ(IFN-γ)increased significantly compared with the control group(P＜0.05),but the incidence of adverse reactions was not statistically significant compared with the control group(P＞0.05).Conclusion Lactic acid bacteria is effective in the treatment of cervical HPV infection,but the side effects are not clear.
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