摘要
目的 探讨甘油三酯-葡萄糖(TyG)指数与多囊卵巢综合征(PCOS)患者胰岛素抵抗(IR)的相关性.方法 选取73例PCOS患者作为研究对象,根据胰岛素抵抗稳态模型评估(HOMA-IR)结果分为IR组24例(HOMA-IR≥2.69)和非IR组(HOMA-IR＜2.69)49例.检测空腹血糖(FPG)、胰岛素(INS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,测量身高和体重,计算体质量指数(BMI).比较两组糖脂代谢指标,并分析TyG与其他指标预测IR的诊断效能.结果 PCOS患者血脂异常率为52.05％.IR组的BMI、FPG、INS、HOMA-IR、TC、TG、LDL-C、TyG、LDL-C/HDL-C、TG/HDL-C和血脂异常率均显著高于非IR组,差异有统计学意义(P＜0.05).TyG预测IR的受试者工作特征曲线(ROC)下的面积(AUC)为0.825,截断值为8.625,敏感度和特异度分别为70.8％和81.6％.结论 TyG是一种预测PCOS合并IR较好的生物标志物.
Abstract
Objective To investigate the correlation between triglyceride-glucose(TyG)index and insulin resistance(IR)in patients with polycystic ovary syndrome(PCOS).Methods 73 patients with PCOS were selected as the study object,and were divided into 24 patients in the IR group(HOMA-IR≥2.69)and 49 patients in the non-IR group(HOMA-IR＜2.69)according to the results of homeostasis model assessment of insulin resistance(HOMA-IR＜2.69).Fasting blood glucose(FPG),insulin(INS),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)levels,height and weight were measured.Body Mass index(BMI).The glucolipid metabolism indexes of the two groups were compared,and the diagnostic efficacy of TyG and other indexes in predicting IR was analyzed.Results BMI,FPG,INS,HOMA-IR,TC,TG,LDL-C,TyG,LDL-C/HDL-C,TG/HDL-C and dyslipidemia rates in IR group were significantly higher than those in non-IR group,with statistical significance(P＜0.05).The area(AUC)under receiver operating characteristic curve(ROC)predicted by TyG for IR was 0.825,the cutoff value was 8.625,and the sensitivity and specificity were 70.8％and 81.6％,respectively.Conclusion TyG is a good biomarker for predicting PCOS combined with IR.
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