The relationship between umbilical cord blood IGFBP-3,IGFBP-5 levels and intrauterine infection in pregnant women with premature rupture of membranes
Objective To investigate the relationship between the levels of insulin growth factor binding protein-3(IGFBP-3)and insulin-like growth factor binding protein-5(IGFBP-5)in umbilical cord blood and intrauterine infection in pregnant women with premature rupture of membranes.Methods 80 pregnant women with premature rupture of membranes were selected and divided into infected group(40 cases)and uninfected group(40 cases)according to whether intrauterine infection occurred after delivery.The levels of IGFBP-3 and IGFBP-5 in cord blood of the two groups were compared and the predictive value was evaluated.Results The levels of IGFBP-3 and IGFBP-5 in cord blood of infected group were higher than those of uninfected group(P＜0.05).The combined prediction AUC of IGFBP-3 and IGFBP-5 in cord blood was 0.908.Multivariate Logistic regression analysis showed that IGFBP-3,IGFBP-5 and the time from membrane rupture to delivery(OR=2.523,95％CI:1.676,3.788)were all risk factors for intrauterine infection in pregnant women with term premature rupture of membranes(OR＞1)(P＜0.05).Conclusion The levels of IGFBP-3 and IGFBP-5 in the cord blood of pregnant women with PROM complicated with intrauterine infection were highly expressed,and they can be used as clinical indicators for the diagnosis of intrauterine infection,and the combined prediction has higher diagnostic efficacy.
万方数据
维普
