Observation of the therapeutic effect of different doses of letrozole combined with HMG on ovulation induction in patients with polycystic ovary syndrome
Objective To explore the effect of different doses of letrozole combined with urinary gonadotropin(HMG)on ovulation promotion in patients with polycystic ovary syndrome(PCOS).Methods 30 patients with PCOS were screened and divided into control group(2.5 mg letrozole+HMG treatment)and research group(5.0 mg letrozole+HMG treatment)with 15 cases in each group,and the therapeutic effect of the two groups was compared.Results Compared with the control group,the human chorionic gonadotropin(HCG)daily ≥15 mm and ≥18 mm follicles in the study group had more follicles,the HMG use time and follicle maturation time were shorter,the HMG dosage was less,and the endometrial thickness and blood flow index were higher in the study group after treatment.The levels of testosterone(T),estradiol(E2),luteinizing hormone(LH)and follicle estrogen(FSH)were higher(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion In the treatment of ovulation induction in PCOS patients,5.0mg of letrozole combined with HMG is ideal.
万方数据
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