A clinical study on the relationship between thyroid hormone levels and perinatal outcomes in preeclampsia
Objective To explore the relationship between thyroid hormone levels in late pregnancy pregnant women and the severity of preeclampsia,as well as pregnancy outcomes.Methods 140 pregnant women with preeclampsia who underwent regular prenatal checkups and gave birth in our hospital were selected as the research subjects,further divided into mild preeclampsia group(98 cases)and severe preeclampsia group(42 cases).104 healthy pregnant women who underwent prenatal check ups during the same period and gave birth in our hospital were included as the control group.Detect the serum levels of thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free tetraiodothyronine(FT4),and thyroid peroxidase antibody(TPO-Ab)in the above study subjects using chemiluminescence method,and prospectively track the fetal growth outcomes in the preeclampsia group.Results Compared with the control group,the TSH and TPO-Ab levels in the mild preeclampsia group and the severe preeclampsia group significantly increased,while FT3 The FT4 level significantly decreased,and the TSH and TPO-Ab levels in the severe preeclampsia group were significantly higher than those in the mild preeclampsia group,while FT3 The FT4 level was significantly lower than that of the mild preeclampsia group(P＜0.05).The incidence of hypothyroidism,subclinical hypothyroidism,and TPO Ab positivity with normal thyroid function in the severe preeclampsia group was significantly higher than that in the control group and mild preeclampsia group.The incidence of hypothyroidism,subclinical hypothyroidism,and TPO Ab positivity with normal thyroid function in the mild preeclampsia group was significantly higher than that in the control group(P＜0.05).The gestational age,newborn birth weight,and Apgar score of the severe preeclampsia group were significantly lower than those of the control group and the mild preeclampsia group.The gestational age,newborn birth weight,and Apgar score of the mild preeclampsia group were significantly lower than those of the control group.Fetal growth restriction,fetal distress,placental abruption The incidence of HELLP syndrome and induction of labor were highest in the severe preeclampsia group(P＜0.05).The severity of preeclampsia,thyroid dysfunction,and normal thyroid function but positive TPOAb are all risk factors for premature birth(P＜0.05).The severity of preeclampsia and thyroid dysfunction are risk factors for low birth weight outcomes in fetuses(P＜0.05).Conclusion The severity of preeclampsia and thyroid dysfunction are both associated with a high risk of preterm birth and low birth weight.Monitoring thyroid function in pregnant women with preeclampsia can help predict adverse pregnancy outcomes for the fetus.
万方数据
维普
