脑小血管病认知障碍与脑白质高信号分级及脑萎缩分级相关研究
The study on the correlation between cognitive impairment of cerebral small vessel disease and white matter hyperintensity grade and cerebral atrophy grade
刘婷 1职瑾 2刘仲仲 3王芳 2孟凤珠 2蔺雪梅 4王燕4
作者信息
- 1. 西安市第一医院影像科,陕西 西安 710002
- 2. 西安市第一医院老年神经内科,陕西 西安 710002
- 3. 西安市第一医院老年病研究室,陕西 西安 710002
- 4. 西安市第一医院神经内科,陕西 西安 710002;西安市神经免疫疾病创新转化重点实验室,陕西 西安 710002
- 折叠
摘要
目的 探讨脑小血管病(CSVD)认知障碍与脑白质高信号分级及脑萎缩分级之间的相关性.方法 回顾性分析213例CSVD患者资料,采用头颅MR检查半定量Fazekas直观评分评估脑白质高信号,全脑皮层萎缩分级评价脑萎缩情况.使用认知功能评估工具包括简易精神状态量表(MMSE)、蒙特利尔认知评估量表(Mo CA)对每位患者进行评估.比较不同Fazekas分级及脑萎缩分级患者之间MMSE及Mo CA评分的差异.结果 不同性别CSVD患者的年龄有统计学差异(P=0.04,t=4.288),男性平均年龄[(66.5±10.3)岁]小于女性[(69.5±10.0)岁].不同性别患者与高血压病史之间有统计学差异(P=0.02,t=5.424).脑白质高信号Fazekas分级与MMSE及Mo CA评分之间均有统计学差异(P<0.001,χ2=5.639;P<0.001,χ2=5.843),全脑皮层萎缩分级与MMSE评分有统计学差异(P=0.036,χ2=2.895).结论 CSVD认知功能障碍与头颅MR影像学评估分级存在一定相关性.
Abstract
Objective To investigate the correlation between cognitive impairment of cerebral small vessel disease(CSVD)and white matter hyperintensity grade and cerebral atrophy grade.Methods The data of 213 patients with CSVD were analyzed retro-spectively.The semi-quantitative Fazekas visual score of brain MR was used to evaluate the white matter hyperintensity,and cerebral atrophy was evaluated by the whole cerebral cortex atrophy grade.Mini-mental state examination(MMSE)and Montreal cognitive assessment(Mo CA)were used to evaluate each patient and to classify according to the results.Results There was a statistically sig-nificant difference in age between male and female patients with CSVD(P=0.04,t=4.288).The mean age of males[(66.5±10.3)years]was less than females[(69.5±10.0)years].There was significant difference between patients with different gender and history of hypertension(P=0.02,t=5.424).There were statistical differences between white matter hyperintensity Fazekes grade and MMSE and Mo CA scores(P<0.001,χ2=5.639;P<0.001,χ2=5.843),and there were statistical differences between whole cerebral cortex atrophy grade and MMSE score(P=0.036,χ2=2.895).Conclusion There is a certain correlation between cognitive impairment of CSVD and head MR imaging evaluation grade.
关键词
脑小血管病/脑白质高信号分级/全脑皮层萎缩分级/认知障碍Key words
cerebral small vessel disease/white matter hyperintensity grade/whole cerebral cortex atrophy grade/cognitive impairment引用本文复制引用
出版年
2025
NETL
NSTL
万方数据