摘要
目的 探讨磁共振血管成像(MRA)联合CXC基序趋化因子配体12(CXCL12)预测短暂性脑缺血发作(TIA)患者缺血性脑卒中发生的效能.方法 选取225例TIA患者,所有患者治疗前均行MRA、CXCL12检查.患者治疗1周内统计TIA患者缺血性脑卒中发生情况,分析影响TIA患者发生缺血性脑卒中的因素,分析MRA联合CXCL12预测TIA患者发生缺血性脑卒中的价值.结果 225例患者中21例发生缺血性脑卒中.多因素logistic回归分析显示埃森卒中风险评分量表(ESRS)评分、病变部位狭窄度、CXCL12水平是影响TIA患者发生缺血性脑卒中的因素(P<0.05).受试者工作特征(ROC)曲线分析显示,病变部位狭窄度、CXCL12及二者联合预测TIA患者发生缺血性脑卒中的敏感度分别为76.19%、71.43%、85.71%,特异度分别为80.39%、70.10%、88.73%,曲线下面积(AUC)分别为0.798、0.733、0.895.结论 MRA联合CXCL12预测TIA患者发生缺血性脑卒中的效能良好.
Abstract
Objective To explore the efficacy of magnetic resonance angiography(MRA)combined with CXC motif chemokine ligand 12(CXCL12)in predicting ischemic stroke in patients with transient ischemic attack(TIA).Methods A total of 225 patients with TIA were selected,and all patients underwent MRA and CXCL12 examination before treatment.The occurrence of ischemic stroke in TIA patients was counted within 1 week of treatment,the factors influencing the occurrence of ischemic stroke in TIA patients were analyzed,and the value of MRA combined with CXCL12 in predicting the occurrence of ischemic stroke in TIA patients was ana-lyzed.Results Among the 225 patients,21 of them had ischemic stroke.Multivariate logistic regression analysis showed that Essen stroke risk scale(ESRS)score,lesion site stenosis,and CXCL12 level were the factors influencing the occurrence of ischemic stroke in TIA patients(P<0.05).The receiver operating characteristic(ROC)curve showed that the sensitivity of lesion site stenosis,CXCL12 and their combination in predicting the occurrence of ischemic stroke in TIA patients was 76.19%,71.43%,and 85.71%,respectively,the specificity was 80.39%,70.10%,and 88.73%,respectively,and the area under the curve(AUC)was 0.798,0.733,and 0.895,respectively.Conclusion MRA combined with CXCL12 has good efficacy in predicting the occurrence of ischemic stroke in TIA patients.
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