Correlation of serum p38 level with myelosuppression after chemotherapy for non-small cell lung cancer
Objective To investigate the correlation between serum P38 level and myelosuppression in patients with non-small cell lung cancer after chemotherapy.Methods A total of 130 patients diagnosed as NSCLC were selected.Enzyme-linked immunosorbent assay(ELISA)was used to detect the expression levels of p38 in serum before and after chemotherapy.The incidence of myelosuppression was recorded,and the correlation between serum p38 levels after chemotherapy and the degree of bone marrow suppression was analyzed.Results The patients were divided into a severe group(n=27),a mild group(n=83),and a normal group(n=20)based on graduation standard for myelosuppression.The incidence of chemotherapy-induced myelosuppression after chemotherapy was 84.6％.The serum p38 levels increased significantly after chemotherapy(P＜0.05).There was a positive correlation between serum p38 levels after chemotherapy and the grading of bone marrow suppression,which was statistically significant(r=0.517,P＜0.05).Conclusion The level of Serum p38 is correlated with myelosuppression after chemotherapy in non-small cell lung cancer,and p38 may be involved in the occurrence of myelosuppression after chemotherapy.
万方数据
维普
