Value of early neutrophil-to-lymphocyte ratio combined with procalcitonin in the diagnosis of severe acute pancreatitis and the procalcitonin of a clinical prediction model
Objective To investigate the values of serum neutrophil to lymphocyte ratio(NLR)and procalcitonin(PCT)levels in patients at admission for predicting severe acute pancreatitis(SAP)and to construct a clinical prediction model.Methods One hundred and twelve patients with AP admitted to our hospital from September 2021 to September 2022 were selected and divided into a SAP group(n=58)and a non-SAP group(n=54)according to the disease severity.The general clinical characteristics datas and peripheral blood laboratory indexes within 24 h of admission were collected from both groups.The risk factors associated with the SAP and non-SAP groups were analyzed and forest plots were drawn.Independent risk factors were screened using multifactorial logistic regression analysis.Receiver operating characteristic curves(ROC)were drawn and clinical prediction models were constructed,and the area under the curve,sensitivit,and specificity of different indexes were compared.Results The differences between the 2 groups were significant(P＜0.05)in systolic blood pressure at admission,days of hospitalization,and combined underlying disease(hypertension).White blood cell(WBC),neutrophil(NE),lymphocyte(L),NLR,platelet to lymphocyte ratio(PLR),total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL),Ca2+,apolipoprotein A1(APO A1),apolipoprotein A2(APO A2),serum creatinine(SCR),albumin(ALB),glucose(Glu),C-reaction protein(CRP),PCT,prothrombin time(PT),and D-dimer were related to AP severity(all P＜0.05).Multifactorial logistic regression analysis showed that NLR,APO A1,APO A2,Glu,and PCT were independent risk factors for AP severity(P＜0.05).ROC curve analysis showed that NLR,PCT,NLR+PCT,and clinical model predicted AP severity of AUC(95%CI)were 0.786(0.702～0.869),0.744(0.651～0.838),0.883(0.822～0.944),and 0.964(0.096～1.000),respectively.Conclusion NLR and PCT are independent risk factors influencing the disease severity of AP and have some predictive value,and the combination of the two has a higher predictive value.
acute pancreatitisearly neutrophil-to-lymphocyte ratioprocalcitoninpredictive value
NETL
NSTL
万方数据
