Levels of miRNAs,inflammatory factors and MRI features in peripheral blood of patients with epileps
Objective To investigate the changes of serum biological substances and head magnetic resonance imaging(MRI)features in patients with epilepsy,and lay a foundation for further research on the pathogenesis and clinical characteristics of epilepsy.Methods Thirty patients with unilateral temporal lobe epilepsy(TLE)(TLE group)and thirty healthy subjects(control group)were selected as participants.The brain MRI features of the patients were investigated.Differences in bilateral hippocampal T2 relaxation time(HCT2)and levels of peripheral blood T lymphocyte subsets(CD3+,CD4+,CD8+and CD4+/CD8+),inflammatory factor(TNF-α,IL-1β,IL-2,IL-6,IL-10 and ICAM-1),miRNAs(miR-146a,miR-210,miR-221,miR-34a,miR-135b,and miR-33)between the 2 groups were compared.Results Compared with the control group,the volume of the hippocampus in the TLE group was significantly reduced,and the HCT2 in the epilepsy group was higher(P<0.05);the levels of peripheral blood T lymphocyte subsets CD3+,CD4+and CD4+/CD8+,inflammatory factors TNF-α,IL-1β,IL-2,IL-6 and ICAM-1,and miR-146a,miR-210,miR-221 and miR-34a were distinctly increased in the TLE group(all P<0.05);however,the expression levels of CD8+,IL-10,miR-33 and miR-135b in T lymphocyte subsets were remarkably decreased in the TLE group(all P<0.05).Conclusion The pathological changes in the hippocampus of TLE patients may be related to the imbalance of T lymphocyte subsets in peripheral blood,chronic inflammatory response,and abnormal miRNA.Thus,controlling the inflammatory response of the hippocampus can reduce the occurrence of epileptic seizures.
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