The predictive value of novel biomarkers for severe mycoplasma pneumoniae pneumonia in children
Objective To investigate the value of novel biomarkers in predicting early severe mycoplasma pneumoniae pneumonia(MPP)in children.Methods A total of 86 children with MPP admitted to Fourth People's Hospital of Langfang City from August 2019 to August 2022 were selected as the research subjects.After 1 week of treatment,the children were divided into a mild group(n=56)and a severe group(n=30)according to clinical signs,imaging findings and related literature.The general clinical data and the levels of interleukin-6(IL-6),serum amyloid A(SAA),lactate dehydrogenase(LDH),prealbumin(PA)and D-dimer after admission were compared between the 2 groups.Multivariate logistic regression analysis was performed for severe MPP,and receiver operating characteristic(ROC)curve was used to analyze the efficacy of each biomarker alone and in combination to predict severe MPP.Results The proportion patients with fever or complications,length of hospital stay,neutrophil count(NEUT),platelet count(PLT),and C-reactive protein(CRP)levels in the severe group were higher than those in the mild group(all P<0.05).There were no significant differences in age,gender,course of disease,proportions of cough,rale and abnormal chest X-ray,and levels of procalcitonin(PCT)and white blood cell(WBC)(P>0.05).The levels of IL-6,SAA,LDH and D-dimer in the severe group were higher than that the in the mild group(P<0.05),but the level of PA was lower(P<0.05).Multivariate logistic regression analysis showed that IL-6,SAA,LDH,PA and D-dimer were independent risk factors for severe MPP(all P<0.05).The area under the curve(AUC)of IL-6,SAA,LDH,PA,and D-dimer to predict severe MPP were 0.791,0.772,0.738,0.720,0.687,0.927,respectively,and the AUC of combined prediction was higher than that of single prediction of above indicators(Z=3.095,3.684,3.799,4.091,5.185,all P<0.05).Conclusion IL-6,SAA,LDH,PA,and D-dimer are related to the occurrence of severe MPP,and combined detection can improve the predictive value.
severe mycoplasma pneumoniae pneumonia(MPP)childreninterleukin 6serum amyloid Alactate dehydrogenaseprealbuminD-dimer
万方数据
维普
