Research on the mechanism of L-theanine regulating lymphocyte cytokine secretion based on network pharmacology
Objective The potential mechanism of L-theanine in regulating cytokine secretion was predicted using network pharmacology methods.Methods The Swiss Target Prediction and TargetNet databases were utilized to predict the targets of L-theanine,while the GeneCards,TTD,and OMIM databases were used to predict targets related to immune cytokine secretion.Finally,the online tool Venny 2.1 was employed to identify their intersection,which was then subjected to PPI analysis,GO enrichment analysis,and KEGG enrichment analysis.Results The network pharmacology results revealed 81 common targets of L-theanine and immune cytokine secretion.Among these,core targets such as IL-1B,TLR4,NFκB1,MMP9,EGFR,and JUN may be involved in the action of L-theanine.KEGG enrichment analysis further suggested that the effects of L-theanine may be associated with the estrogen signaling pathway,relaxin signaling pathway,cAMP signaling pathway,and cGMP-PKG signaling pathway.Conclusion The mechanism by which L-theanine regulates cytokine secretion may be related to its action on targets such as IL-1B,TLR4,NFκB1,MMP9,EGFR,and JUN,thereby modulating the estrogen,relaxin,cAMP,and cGMP-PKG signaling pathways.
万方数据
维普
