Mechanism on anti-Parkinson's disease activity of Eleutherococcus senticosus based on network pharmacology
Objective To investigate the mechanism and molecular targets of Eleutherococcus senticosus in the treatment of Parkinson's disease(PD).Methods The active ingredients of Eleutherococcus senticosus were obtained and screened from the ETCM database,and their corresponding targets were predicted using the Swiss Target Prediction platform,where the network diagram of"E.senticosus-active compound-gene target"was constructed.The gene targets of PD were obtained from GeneCards and DisGeNET,and their intersection with the E.senticosus gene targets was screened based on degree value,mediation centrality,and proximity centrality.STRING database was used to construct a network diagram of PPI,followed by the enrichment analysis of GO and KEGG.Finally,molecular docking was performed using AutoDock Vina.Results A total of 652 of 61 bioactive compounds in E.senticosus were retrieved,and 652 potential targets were identified,including 506 potential disease targets probabely suitable for treating PD.The results of molecular docking show that eleutheroside B,quercetin,and β-sitosterol were the core active components of E.senticosus in the treatment of PD,and they could act on GAPDH,AKT1,and TNF,respectively.Conclusion It is speculated that E.senticosus may play a role in improving the treatment of PD mainly through the interaction of neuroactive ligand-receptor and cAMP signaling pathway.
万方数据
维普
