首页|超声半定量评分结合瞬时弹性成像技术评估乙型肝炎肝硬化并发食管静脉曲张价值研究

超声半定量评分结合瞬时弹性成像技术评估乙型肝炎肝硬化并发食管静脉曲张价值研究

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目的 探讨采用超声半定量评分联合瞬时弹性成像技术评估乙型肝炎肝硬化患者并发食管静脉曲张(EV)的价值。方法 2020 年4 月~2023 年4 月我院诊治的乙型肝炎肝硬化患者116 例,所有受试者均接受胃肠镜检查,评估EV程度。常规行肝脏超声检查并评估超声半定量评分,使用Fibroscan行肝脏硬度检测(LSM)。采用Logistic多因素分析,应用受试者工作特征曲线(ROC)并根据曲线下面积(AUC)评估各指标评估乙型肝炎肝硬化发生中重度EV的诊断价值。结果 在本组患者中,胃镜检出EV者72 例(62。1%),其中轻度 30 例(41。7%)、中度 24 例(33。3%)和重度 18例(25。0%);中重度患者超声半定量评分为(13。2±1。6)分,显著高于轻度组[(11。7±1。3)分,P<0。05]或无EV组[(10。4±1。2)分,P<0。05];中重度EV患者LSM为(23。9±4。2)kPa,显著大于轻度EV患者[(18。1±3。7)kPa,P<0。05]或无EV患者[(13。6±2。1)kPa,P<0。05];多因素分析显示,超声半定量评分和LSM均是影响中重度EV发生的独立危险因素(P<0。05);ROC分析显示,超声半定量评分联合LSM评估中重度EV发生的灵敏度和特异度分别为78。6%和83。8%,显著优于两指标单独预测(P<0。05)。结论 超声半定量评分联合瞬时弹性成像技术评估乙型肝炎肝硬化患者并发EV的严重程度具有一定的临床应用价值,值得进一步探讨。
Evaluation of esophageal varices by semi quantitative ultrasound scoring and elastography in patients with hepatitis B viral infection-induced liver cirrhosis
Objective This study was conducted to explore the evaluation of esophageal varices(EV)by semi quantitative ultrasound scoring(SQUS)and elastography in patients with hepatitis B viral infection-induced liver cirrhosis(LC).Methods 116 patients with hepatitis B-induced LC were encountered in our hospital between April 2020 and April 2023,and all patients underwent esophagogastroscopy as the gold standard for the diagnosis of EV.Simultaneously,the SQUS was evaluated by ultrasonography,and the liver stiffness measurement(LSM)was detected by transient elastography.The multivariate Logistic regression analysis was applied to reveal the risk factors and the area under the receiver operating characteristic curve was applied to evaluate the diagnostic performance.Results Out of our series,the esophagogastroscopy found patients with EV in 72 cases(62.1%),including mild EV in30 cases(41.7%),moderate in 24 cases(33.3%)and severe in 18 cases(25.0%);the SQUS in 42 patients with moderate/severe EV was(13.2±1.6),much higher than[(11.7±1.3),P<0.05]in patients with mild EV or[(10.4±1.2),P<0.05]in individuals without EV;the LSM in patients with moderate/severe EV was(23.9±4.2)kPa,significantly greater than[(18.1±3.7)kPa,P<0.05]in patients with mild EV or[(13.6±2.1)kPa,P<0.05]in individuals without EV;the Logistic regression analysis showed that the SQUS and LSM were both the independent risk factors for the occurrence of moderate/severe EV(P<0.05);the ROC analysis demonstrated the sensitivity and specificity were 78.6%and 83.8%,respectively,when the SQUS and LSM was combined in predicting the moderate/severe EV,much superior to any parameter did alone(P<0.05).Conclusion The diagnostic efficacy of SQUS and LSM combination in predicting the severity of EV in patients with LC is promising,and warrants further clinical investigation.

Liver cirrhosisEsophageal varicesSemi quantitative ultrasound scoringLiver stiffness measurementDi-agnosis

宋一凡、郑帅、许芸、唐铁骑

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100073 北京市 北京电力医院超声科

首都医科大学附属北京天坛医院超声科

肝硬化 食管静脉曲张 超声半定量评分 肝脏硬度检测 诊断

北京市自然科学基金资助项目

7202068

2024

实用肝脏病杂志
中华医学会安徽分会

实用肝脏病杂志

CSTPCD
影响因子:1.362
ISSN:1672-5069
年,卷(期):2024.27(1)
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