首页|肝细胞癌组织HOXC9和KIF4A表达及其临床意义探讨

肝细胞癌组织HOXC9和KIF4A表达及其临床意义探讨

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探讨肝细胞癌(HCC)患者癌组织同源盒基因C9(HOXC9)和驱动蛋白家族成员4A(KIF4A)蛋白表达及其临床意义。方法 2018 年1 月～2021 年1 月我院收治的86 例HCC患者，行肝叶手术治疗，取癌组织和癌旁肝组织，采用免疫组织化学染色法检测组织HOXC9 和KIF4A蛋白表达。随访 2 年。结果 HCC癌组织HOXC9 和KIF4A高表达阳性率分别为69。8%和51。2%，均显著高于癌旁肝组织的15。1%和16。3%，差异具有统计学意义(P<0。05);56 例肿瘤细胞低/中分化、40 例Ⅱb/Ⅲb期TNM分期、38 例有肿瘤包膜侵犯和37 例微血管侵犯患者癌组织HOXC9 蛋白高表达阳性率分别为78。6%、85。0%、71。1%和83。8%，均显著高于30 例高分化、46 例Ⅰa/Ⅱa期TNM分期、48 例无肿瘤包膜侵犯和49 例无微血管侵犯患者癌组织(分别为53。3%、56。5%、47。9%和59。2%，P<0。05);肿瘤细胞低/中分化、Ⅱb/Ⅲb期TNM分期、肿瘤包膜侵犯和微血管侵犯患者癌组织KIF4A蛋白高表达阳性率分别为60。7%、80。0%、60。5%和89。2%，也显著高于对应组癌组织表达(分别为 33。3%、26。1%、43。8%和 22。4%，P<0。05);在随访结束时，86 例患者生存 38 例(44。2%)，死亡48 例(55。8%);60 例癌组织HOXC9 蛋白高表达患者生存时间为 14。0(7。8，26。7)个月，显著短于 26 例HOXC9 蛋白低表达患者[27。0(18。8，30。5)个月，P<0。05];44 例癌组织KIF4A蛋白高表达患者生存时间为 9。0(7。0，26。3)个月，也显著短于 42 例 HOXC9 蛋白低表达患者[15。3(26。0，28。8)个月，P<0。05]。结论 HCC 患者癌组织HOXC9 和KIF4A蛋白高表达可能与肿瘤细胞恶性程度相关，并影响肝叶手术治疗后预后，值得深入研究。
Intensified hepatic expressions of HOXC9 and KIF4A proteins is correlated to poor prognosis in patients with hepatocellular carcinoma
Objective The aim of this study was to explore the implications of hepatic homeobox gene C9(HOXC9)and kinesin family member 4A(KIF4A)protein expression in patients with hepatocellular carcinoma(HCC).Methods 86 patients with HCC were enrolled in our hospital between January 2018 and January 2021,and all underwent hepatectomy.The patients with HCC were all followed-up for two years after operation.The cancerous and the adjacent non-cancerous tissues were collected,and the protein expressions of HOXC9 and KIF4A in tissues were detected by immunohistochemical staining.Results The intensified expression rates of HOXC9 and KIF4A in cancerous tissues were 69.8%and 51.2%,both significantly higher than 15.1%and 16.3%in adjacent liver tissues(P<0.05);the intensified expression rates of HOXC9 in 56 patients with low/moderate tumor cell differentiation,in 40 patients withⅡb/Ⅲb stages,in 38 patients with tumor capsule invasion and 37 patients with microvascular invasion were 78.6%,85.0%,71.1%and 83.8%,all significantly higher than 53.3%,56.5%,47.9%and 59.2%(P<0.05)in 30 patients with high tumor cell differentiation,in 46 patients withⅠa/Ⅱa stages,in 48 patients without tumor capsule invasion and in 49 patients without microvascular invasion;the intensified expression rates of KIF4A in low/moderate tumor cell differentiation,Ⅱb/Ⅲb stages,with tumor capsule invasion and microvascular invasion were 60.7%,80.0%,60.5%and 89.2%,also significantly higher than 33.3%,26.1%,43.8%and 22.4%(P<0.05)in their parallel adjacent non-cancerous tissues;at the end of two-year follow-up,38 patients(44.2%)survived and 48 patients(55.8%)died;the overall survivals(OS)in 60 patients with intensified cancerous HOXC9 expression was 14.0(7.8,26.7)mon,much shorter than[27.0(18.8,30.5)mon,P<0.05]in 26 patients with weak HOXC9 expression;the OS in 44 patients with intensified cancerous KIF4A expression was 9.0(7.0,26.3)mon,also significantly shorter than[15.3(26.0,28.8)mon,P<0.05]in 42 patients with weak HOXC9 expression.Conclusion The upregulation of cancerous HOXC9 and KIF4A in patients with HCC might be correlated to the malignant quality of tumor cells,and to the poor prognosis.

HepatomaHepatectomyHomeobox gene C9Kinesin family member 4APrognosis

何圣科、蒲江汉、冯海玲、吴大平、陈绵军、陈辉

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571700 海南省儋州市海南医学院附属儋州市人民医院病理科

571700 海南省儋州市海南医学院附属儋州市人民医院肿瘤内科

571700 海南省儋州市海南医学院附属儋州市人民医院重症医学科

海南省肿瘤医院病理科

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肝细胞癌 同源盒基因C9 驱动蛋白家族成员4A 肝叶切除术 预后

海南省医药卫生科研计划项目

21A200180

2024

10.3969/j.issn.1672-5069.2024.01.022

实用肝脏病杂志
中华医学会安徽分会

实用肝脏病杂志

CSTPCD
影响因子：1.362
ISSN：1672-5069
年,卷(期)：2024.27(1)
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