Macrographic phenotype of docosahexaenoic acid metabolism plays a role in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis(NASH),with pathological characteristics of hepatic steatosis,ballooning,and lobular inflammation,reflects the chronic liver disases induced by metabolic stress.Here,we summarize the regulatory effect of gut microbia-derived butyrate on the docosahexaenoic acid(DHA)metabolic phenotype of hepatic mononuclear phagocyte system through HDAC/12/15-LOX/maresin signaling.Its role in NASH amelioration is further reviewed on the basis of proinflammatory mediators/maresins rebalancing and spontaneous resolution of inflammation.
国家科技期刊平台
NSTL
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