Distribution and drug resistance of pathogens in patients with decompensated hepatitis B cirrhosis and spontaneous bacterial peritonitis
Objective The aim of this study was to investigate the distribution and drug resistance of pathogens in patients with decompensated hepatitis B liver cirrhosis(LC)and spontaneous bacterial peritonitis(SBP).Methods A series of 559 patients with decompensated hepatitis B-induced LC were admitted to our hospital between January 2019 and January 2023,and the ascites were obtained for routine bacterial culture.The bacterial characterization and drug susceptibility were conducted by VITEK-2 compact automatic microbial identification system.Results Among the 559 patients with decompensated LC,the ascites bacterial culture was positive in 119 cases(21.3％),including 74 strains(62.2％)of Gram-negative bacteria,35 strains(29.4％)of Gram-positive bacteria and 10 strains(8.4％)of fungi infection;the Escherichia Coli was resistant to ampicillin up to 97.1％,the resistance to ciprofloxacin and first-generation,second-generation and third-generation cephalosporins greater than 40.0％,and was sensitive to amicacin and ertapenem;the Klebsiella Pneumoniae was resistant to ampicillin up to 100.0％,while sensitive to other commonly administered antibiotics;the Enterobacter Cloacae was resistant to cephalosporins greater than 30.0％,but sensitive to amikacin,gentamicin and ertapenem;the coagulase-negative Staphylococcus,Staphylococcus Aureus and Enterococcus Faecium was resistant to penicillin greater than 80.0％,but sensitive to vancomycin,tigacycline and linezolid;the Fungi we found were all sensitive to common antifungal agents.Conclusion The main pathogens in patients with SBP are Gram-negative bacteria in our hospital,and the drug resistance is common.In clinical practice,the early ascites culture and bacterial characterization are necessary for sensitive antibiotics selection.
国家科技期刊平台
NSTL
万方数据
维普
