Diagnostic performance of serum SPINK1 levels for hepatocellular carcinoma in patients with hepatitis B-induced liver cirrhosis
Objective The purpose of this study was to investigate the diagnostic performance of serum serine protease inhibitor Kazal type 1(SPINK1)levels for hepatocellular carcinoma(HCC)in patients with hepatitis B-induced liver cirrhosis(LC).Methods A total of 204 consecutive patients with hepatitis B-induced LC were encountered in our hospital between April 2020 and April 2023,andall underwent dynamic contrast-enhanced magnetic resonance imaging(MRI).The patients who had intrahepatic space-occupying lesions received fine needle aspiration biopsies(FNAB)for histo-pathological examination.Serum SPTINK1 and alpha-fetoprotein(AFP)levels were detected by ELISA.The multivariate Logistic regression analysis and receiver-operating characteristic curve(ROC)were applied to predict the diagnostic efficacy.Results Out the 204 patients with hepatitis B-induced LC,the intrahepatic space-occupying lesions were found in 30 cases(14.7％)by MRI,and the histo-pathological examination showed all with HCC;serum SPTINK1 and AFP levels in patients with HCC were(23.9±5.2)ng/mL and(426.5± 67.0)ng/mL,both significantly higher than[(7.4±2.1)ng/mL and(14.4±4.3)ng/mL,respectively,P＜0.05]in those with LC;both serum SPTINK1(OR:3.69,95％CI:1.08-12.49)and AFP(OR:3.54,95％CI:1.04-11.98)were positively correlated to HCC existence;the AUC was 0.80(95％CI:0.72-0.89),with the sensitivity(Se)of 71％and the specificity(Sp)of 73％,when serum AFP level equal to or greater than 360.1 ng/mL was set as the cut-off-value,and the AUC was 0.82(95％CI:0.74-0.91),with the Se of 82％and the Sp of 79％,when serum SPTINK1 level equal to or greater than 15.6 ng/mL was set as the cut-off-value in diagnosing HCC.Conclusion The elevated serum SPINK1 and AFP levels might hint the malignant tumor in LC patients with MRI-proven space-occupying lesions,and the FNAB could determine the diagnosis.
HepatomaLiver cirrhosisEnhanced magnetic resonanceProtease inhibitor Kazal type 1Alpha-fetoproteinDiagnosis
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NSTL
万方数据
维普
