摘要
目的 调查非肥胖体检人群胆结石检出率及其危险因素.方法 2021年1月～2021年12月西安交通大学第二附属医院健康管理中心参加体检的非肥胖人群(BMI≤24 kg/m2),行腹部超声和血生化检测.结果 2021年度参加体检人群66221例,超重人群31427例,发现胆结石1591例(5.1％),有胆囊切除术862例(2.7％),非肥胖人群34794例,发现胆结石1309例(3.8％),胆囊切除术657例(1.9％),两组差异显著(P＜0.001);非肥胖胆结石患者女性、年龄大、高 BMI 占比高,SBP、DBP、FBG、TG、TC、LDL-C、UA、ALT、AST、ALP、GGT、TBIL 水平和合并脂肪肝者更高(P＜0.001);采用多因素Logistic回归分析显示年龄、女性、BMI、FBG、GGT和脂肪肝是非肥胖人群胆结石发生的独立危险因素,而HDL-C则为保护性因素(P＜0.001);非肥胖胆结石患者女性占65.0％,≥45岁者占62.4％,高SBP占32.7％,低HDL-C占29.4％、高 LDL-C 占 27.3％、高 TG 占 24.6％、高 DBP 占 21.3％、高 TC 占 21.3％、高 FBG 占 19.6％、脂肪肝占 16.8％和高UA占16.0％.结论 非肥胖人群胆结石检出率显著低于超重人群,但这些人群中的女性、血糖、血脂代谢紊乱和合并脂肪肝者仍可存在胆结石,需要注意监测和防治.
Abstract
Objective The aim of this study was to investigate the prevalence and risk factors of gallstones in non-obese individuals at physical examination.Methods Obese and non-obese persons[body mass index(BMI)≤ 24 kg/m2]attended physical examinations at Health Management Center,Second Affiliated Hospital,Xi'an Jiaotong University between January 2021 and December 2021,and all underwent abdominal ultrasonography and blood biochemical parameter tests.The univariate and multivariate Logistic regression analysis was applied to reveal the risk factors for gallstone formation.Results There were 66221 persons participating the physical examination in 2021 in our hospital,and 31427 of them were overweight or obese,finding 1591 cases(5.1％)with gallstones and 862 cases(2.7％)having cholecystectomy history,while out 34794 non-obese persons found 1309 cases(3.8％)of gallstones and 657 cases(1.9％)having cholecystectomy,significantly different between the two groups(P＜0.001);the gallstones in the non-obese population were more common in females,relatively elderly and those with relative high BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),triglycerides(TG),total cholesterol(TC),high density cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),uric acid(UA),alanine aminotransferase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP),glutamyl transpeptidase(GGT)and total bilirubin(TBIL)levels;the multivariate Logistic regression analyses showed that the age,female,BMI,FBG,fatty liver diseases and GGT levels were all the independent risk factors for gallstone occurrence in the non-obese population,while blood HDL-C level was the protective factors;out the non-obese population,the gallstones were found in 65.0％of women,62.4％of those older than 45 years,32.7％of those with high SBP,29.4％with low serum HDL-C level,27.3％with high serum LDL-C level,24.6％with high serum TG level,21.3％with high DBP,21.3％with high TC level,19.6％with high FBG,16.8％with fatty liver diseases and 16.0％with high UA level.Conclusion The prevalence of gallstones in non-obese population is relatively lower than that in the overweight and obese population,while the entity is not uncommon in the population,especially in female,in those with a variety of relatively metabolic disorders,such as increased blood glucose level,lipid metabolism disorders and fatty liver.
基金项目
国家十三五重点研发计划资助项目(2018YFC1311504)
国家科技期刊平台
NSTL
维普
万方数据